関連する実験動画

Updated: May 15, 2025

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

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コマンダー複合体はリソソーム機能を調節し,パーキンソン病のリスクに関係している

Georgia Minakaki1, Nathaniel Safren1, Bernabe I Bustos1

  • 1Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

Science (New York, N.Y.)
|April 10, 2025
PubMed
まとめ

GBA1の遺伝子変異はパーキンソン病 (PD) とルイ体の認知症 (DLB) と関連しています. 研究者は,GCaseの活性とリソソーム機能に影響を与える重要なタンパク質としてCOMMD3を特定し,神経変性疾患の新たな治療標的を示唆した.

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