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Updated: May 13, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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銅触媒C-B ((sp3) Cu-B ((sp3) の媒介による結合形成 複合体

Zhanqiang Ye1, Chun Yin Kwok1, Sze Lam Lam1

  • 1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, SAR 999077, P. R. China.

Journal of the American Chemical Society
|April 15, 2025
PubMed
まとめ

この研究は,重要な炭素-ボロン ((sp3) 結合を形成する,新しい銅触媒によるアルレンの水酸化を導入する. 独特のディボロン反応剤を使用し,触媒サイクルにおける主要な銅-ボロン ((sp3) 中間物質を確認する.

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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

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β-Dicarbonyl Compounds via Crossed Claisen Condensations

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Hydroboration-Oxidation of Alkenes03:08

Hydroboration-Oxidation of Alkenes

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The method to achieve α-brominated carboxylic acids using a mixture of phosphorus tribromide and bromine is known as the Hell–Volhard–Zelinski reaction. The reaction is catalyzed by phosphorus tribromide, which can be used directly or produced in situ from red phosphorus and bromine. The mechanism comprises PBr3 catalyzed conversion of acid to acid bromide and hydrogen bromide. The acid bromide enolizes to its enol form in the presence of HBr. The nucleophilic enol attacks the...
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A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
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This lesson deals with the crossed aldol reaction using weak bases. The self-condensation of an aldehyde having α hydrogen is prevented by adding it slowly to a mixture of formaldehyde and weak bases like hydroxide and alkoxide. Upon slow addition of the aldehyde, the base deprotonates the α carbon of the aldehyde to form the corresponding enolate. The enolate subsequently attacks the formaldehyde to form a single crossed product. Figure 1 depicts the aforementioned reaction.
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Crossed Aldol Reactions: Overview

Crossed aldol addition is the reaction between two different carbonyl compounds under acidic or basic conditions. Here, both the carbonyl compounds function as nucleophiles and electrophiles. As shown in Figure 1, such a reaction yields a mixture of products, two of which are formed via self-condensation, while the remaining two are formed via crossed-condensation. Without adjustment, the reaction's usefulness in organic chemistry is decreased.
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