関連する実験動画

Updated: May 13, 2025

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

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DNA結合とミトスリン酸化は,ポリグルタミンタンパク質をアセンブリ形成から保護する

Shady Saad1, Tomek Swigut1, Saman Tabatabaee1

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|April 16, 2025
PubMed
まとめ

FOXP2のような転写因子の長いポリグルタミン (polyQ) 経路は,DNA結合またはリン酸化によって溶解性を保ちます. FOXP2のヒト特異的な変化は,その結合を減少させ,ポリQ疾患に対する治療的洞察を提供します.

キーワード:
FOXP2 についてハンティントン病アミロイド進化についてグルタミンに富んだタンパク質人間の言葉言語ポリグルタミンタンパク質アセンブリ転写因子

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Growth Assays to Assess Polyglutamine Toxicity in Yeast09:06

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