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Updated: May 13, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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微生物から派生した胆酸は宿主アンドロゲン受容体に対抗し,抗腫瘍免疫を誘発する

Wen-Bing Jin1, Leyi Xiao2, Mingeum Jeong2

  • 1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA; Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA; Gastroenterology and Hepatology Division, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, Cornell University, New York, NY, USA; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.

Cell
|April 16, 2025
PubMed
まとめ

微生物から派生した胆酸 (BAs) は宿主の健康に影響を与えます. 研究者らは,ヒトのアンドロゲン受容体 (hAR) に敵対する新しいBAを発見し,遺伝子発現に影響を与え,がんに対する新しい治療法を提供しました.

キーワード:
アンドロゲン受容体抗腫瘍免疫胆酸HSDHs胆酸代謝腸内微生物群ホストと微生物の相互作用ミクロバイオタ胆酸

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