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Updated: May 2, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
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Published on: September 19, 2017

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NMRベースのG:G不一致性DNA結合リガンドトラッピングトランジント複合体の合理的な薬物設計

Shuhei Sakurabayashi1,2,3, Kyoko Furuita2, Takeshi Yamada1

  • 1Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (SANKEN), Osaka University, 8-1 Mihogaoka, Osaka, Ibaraki 567-0047, Japan.

Journal of the American Chemical Society
|April 17, 2025
PubMed
まとめ

研究者はNMRを用いて DNA-リガンド複合体を研究し 小分子が不一致のDNAに結合する方法を明らかにしました この理解により,治療用途のための一時的な複雑な構造をターゲットとする新しいリガンドの設計が可能になった.

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