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Updated: Jun 16, 2025

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

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遺伝子発現を解剖し,再プログラムするために,制御DNAを書き換える

Gabriella E Martyn1, Michael T Montgomery1, Hank Jones1

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA 94305, USA.

Cell
|April 17, 2025
PubMed
まとめ

私たちは新しいCRISPRスクリーニングツール "Variant-EFFECTS"を開発し 制御DNAを正確に編集し 遺伝子発現の変化を測定しました この方法はDNA配列の変異が遺伝子活動にどのように影響し,新しい遺伝子編集療法の可能性を明らかにします.

キーワード:
CRISPRについてRNA フローフィッシュ強化剤遺伝子調節高通量スクリーニングコード化されていない変種予測モデルプライム編集配列設計転写因子

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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression08:54

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