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Updated: Jun 16, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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タンパク質分解を標的とするキメラのCD36媒介内細胞症

Zhengyu Wang1, Bo-Syong Pan2, Rajesh Kumar Manne2

  • 1Department of Pharmacology, The Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Pharmaceutical Science, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Cell
|April 18, 2025
PubMed
まとめ

研究者らは,CD36タンパク質が,タンパク質分解を標的とするキメラ (PROTAC) のような大きな薬物の吸収を促進することを発見した. 細胞の浸透性と溶解性を改善することによって,PROTACsをCD36と結合させるように変更することで,その抗腫瘍効果が向上します.

キーワード:
ADME についてCD36 についてERO5 と BRO5 の分子プロタック細胞の吸収化学 エンドサイト医学化学エンドサイトーシス極性および大きな分子精密医療接近誘発分子

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