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Updated: May 17, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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標的型タンパク質安定化のためのデウビキチナーゼUSP1の活用

Chao Qian1, Zhen Wang2, Yan Xiong1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of the American Chemical Society
|April 19, 2025
PubMed
まとめ

研究者らは USP1 を用いて新しいデウビキチナーゼ標的化キメラ (DUBTAC) 技術を開発し,がん治療の有望性を示した. これは標的型タンパク質の安定化のための DUBTAC 武器庫を拡張します.

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