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関連する概念動画

Thermosensation01:43

Thermosensation

30.3K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.3K
Nociception01:44

Nociception

27.6K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.6K
Pain01:20

Pain

421
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
421
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

4.4K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
4.4K
Somatosensation01:33

Somatosensation

36.3K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.3K
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

2.7K
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
2.7K

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関連する実験動画

Updated: May 21, 2025

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

Published on: February 10, 2023

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熱感および炎症性疼痛のための分散型コーディングロジック

Nima Ghitani1, Lars J von Buchholtz2, Donald Iain MacDonald1

  • 1National Center for Complementary and Integrative Health, Bethesda, MD, USA.

Nature
|April 24, 2025
PubMed
まとめ

炎症は体感覚神経が 熱と触覚を検知する方法を変化させ 痛みを引き起こします 炎症性痛みや熱過敏症の原因は 直接的な触覚による変化ではなく ノシセプターの活動です

さらに関連する動画

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

20.8K
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

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関連する実験動画

Last Updated: May 21, 2025

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
09:07

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

Published on: February 10, 2023

2.7K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

20.8K
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

16.8K

科学分野:

  • 神経科学
  • 感覚生物学
  • 痛みに関する研究

背景:

  • 感覚神経は触覚,温度,痛み信号を伝達する.
  • これらの神経細胞が刺激をどのようにコードし 炎症がそれをどのように変化させるかを理解することは 痛みの管理に極めて重要です

研究 の 目的:

  • ニューロンのクラスによる熱と機械的刺激のエンコーディングを調査する.
  • 炎症が感覚をどのように変えて 痛みを過敏にさせるかを調べる

主な方法:

  • マルチプレックスされた in situ ハイブリデーションを組み合わせた機能的イメージング
  • 炎症を誘発するプロスタグランジンE2を使用し,神経応答を観察しました.

主要な成果:

  • 繊細な触覚と熱の反応を 完全に分離する
  • 熱と有害な機械的刺激によって 広範囲にわたる神経受容体の活性化
  • 炎症は,TRPV1によって媒介された特定の神経受容体における長期間続く活動と熱感化を引き起こした.
  • 機械的刺激への反応は炎症によってほとんど影響を受けず,神経受容体の活動は触覚性アロディニアと相関していた.

結論:

  • 触覚と温度は 異なる感覚ニューロン集団で 異なる方法でコードされます
  • 炎症は細胞の反応を再構成し 熱過敏や炎症性疼痛を引き起こします
  • 炎症性タクティルアロディニアの鍵となるのがノシセプター活動です