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Updated: May 10, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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腫瘍由来エリトポエチンは,がん免疫における免疫抑制スイッチとして作用する

David Kung-Chun Chiu1, Xiangyue Zhang1, Bowie Yik-Ling Cheng2

  • 1Department of Pathology, Stanford University, Stanford, CA, USA.

Science (New York, N.Y.)
|April 24, 2025
PubMed
まとめ

癌細胞からのエリトポエチン (EPO) は,マクロファージのEPORを通じたシグナル伝達により,免疫抑制性腫瘍微環境 (TME) を生み出します. このEPO/EPOR軸を遮断すると,炎症性TMEと腫瘍の回帰が促進され,免疫療法が強化されます.

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