関連する実験動画

Updated: May 10, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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ヒトのキモカイン-GPCR相互作用ネットワークにおける選択性および乱交性のエンコードとデコード

Andrew B Kleist1, Martyna Szpakowska2, Lindsay J Talbot3

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA; Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, USA; MRC Laboratory of Molecular Biology, Cambridge, UK.

Cell
|April 24, 2025
PubMed
まとめ

研究者は,キモカインとGタンパク質結合受容体 (GPCR) の相互作用を制御する主要な分子決定因子を特定しました. これらの要素を理解することで,治療用途のための新しいケモカインを設計することができます.

キーワード:
GPCR についてケモカイン化学反応データサイエンス機械学習多様性タンパク質とタンパク質の相互作用選択性の決定因子短い線形モチーフ構造化されていないタンパク質

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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells14:02

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