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Updated: May 9, 2025

Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

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ヒストンの長期乳酸化は,先天的な免疫記憶における代謝と表遺伝的再配線を結びつける

Athanasios Ziogas1, Boris Novakovic2, Lorenzo Ventriglia3

  • 1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

Cell
|May 3, 2025
PubMed
まとめ

訓練された免疫は先天的な免疫記憶であり,ヒストン乳化 (H3K18la) のような表遺伝的変化を含みます. このプロセスは乳酸の産生に関連し,免疫反応を高め,BCGワクチン接種後も長期にわたって持続する.

キーワード:
BCG についてバチルス・カルメット・ゲーリンH3K18la乳酸ラクチレーション訓練された免疫

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