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Updated: May 21, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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RAS変異がんにおけるSHOC2RAS相互作用を標的とする

Zachary J Hauseman1, Frédéric Stauffer2, Kim S Beyer2

  • 1Novartis BioMedical Research, Cambridge, MA, USA.

Nature
|May 7, 2025
PubMed
まとめ

研究者らは,SHOC2をRAS ((Q61*) がんの依存性として特定し,新しい標的治療法の開発を可能にしました. SHOC2-RASの相互作用を標的とする小さな分子は癌細胞の成長を阻害し,がん治療のための有望な新しい道を提供します.

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