関連する実験動画
Updated: Aug 17, 2026

07:25
Optogenetic Activation of Zebrafish Somatosensory Neurons using ChEF-tdTomato
Published on: January 31, 2013
まとめ
光学軸索は,体感性タラムスで機能的な接続を形成することができます. この研究では,視覚情報は体感覚皮質によって処理され,神経の可塑性を実証することが示されています.
科学分野:
- 神経科学は神経科学である.
- 神経生物学 神経生物学とは
- センサリーシステム センサリーシステム
背景:
- 光学軸索は通常,視覚的タラミック核に投影する.
- 非視覚的乳頭核 (MG,VB) への初期の投影は一時的なものです.
- MGとVBでは,ターゲットを消去し,スペースを作り出すことによって,永久的なレチノトピック接続を誘導することができます.
研究 の 目的:
- 実験的に誘導された網膜-VB投影が機能するかどうかを判断する.
- タラムスと皮質におけるクロスモダル可塑性の可能性を調査する.
主な方法:
- 新生シリアハムスターは,永久的な網膜-VB投影を作り出すために手術を受けた.
- 神経生理学的記録は,成熟した動物の体感覚皮質 (SI,SII) で行われた.
- 視覚的刺激は,SIとSIIの反応を誘発するために使用されました.
主要な成果:
- 視覚刺激は,手術を受けたハムスターのSIとSIIで,複数のユニットの反応を確実に誘発した.
- 操作されたハムスターは,SIとSIIの視覚野の部分的にレチノトピックな表現を示した.
- 正常なハムスターは,SIとSIIでこれらの視覚的反応を示さなかった.
結論:
- 光道軸索は,タラミック体感覚核 (VB) の内部で機能的なシナプスを形成することができます.
- 神経構造は,その主体以外の感覚様式のための機能を仲介することができます.
- これは,クロスモダルの神経可塑性に対する大きな可能性を示している.
関連する概念動画
The Retina
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Sensory Perception: Organization of the Somatosensory System
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
Overview of Somatic Sensory Pathways
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...

