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Updated: May 16, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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異常に安定した合成ダイヘム (Bis) -Fe (IV) オクソ:ダイヘム酵素 (MauG) と (BthA) の中間体

Deepannita Samanta1, Sabyasachi Sarkar1, Dinesh Singh2

  • 1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.

Journal of the American Chemical Society
|May 14, 2025
PubMed
まとめ

研究者は,MauGやBthAのような酵素を模倣した安定したbis-Fe(IV) O中間物質を合成した. この画期的な発見は,酸素原子の移転とC−H活性化におけるヒーム酵素機構とその反応性を理解するのに役立ちます.

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Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
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The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is...
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Characteristics of Dienophiles
Generally, the best dienophiles are alkenes containing electron-withdrawing substituents such as carbonyl, nitrile, and nitro groups. The feasibility of a Diels–Alder...
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