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Updated: May 16, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
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SARS-CoV-2 ORF6のN-ターミナル膜アンカーを明らかにした

Martí Ninot-Pedrosa1, Gyula Pálfy2, Hafez Razmazma1

  • 1Molecular Microbiology and Structural Biochemistry (MMSB), UMR 5086 CNRS, Lyon 69367, France.

Journal of the American Chemical Society
|May 15, 2025
PubMed
まとめ

SARS-CoV-2のORF6タンパク質は細胞毒性であり,インターフェロンを阻害する. この研究は,その螺旋構造,N末端経由の膜アンカリング,および,ウイルス病原性を理解するために重要な脂質二層内のオリゴメリック状態を明らかにしています.

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Tail-anchoring of Proteins in the ER Membrane

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