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Updated: May 21, 2025

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
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Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

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GPCRシグナルゲート 神経伝達物質に対するアストロサイト反応と神経細胞活動の制御

Kevin A Guttenplan1, Isa Maxwell1, Erin Santos1

  • 1Vollum Institute, Oregon Health and Sciences University, Portland, OR, USA.

Science (New York, N.Y.)
|May 15, 2025
PubMed
まとめ

アストロサイトは神経伝達物質の反応を アドレナージック信号で伝達し ニューロンの回路と行動を制御します この保存されたメカニズムは ダイナミックなアストロサイトによる脳活動の調節を明らかにします

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
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