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Updated: May 17, 2025

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

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システム薬剤投与のためのOEGylated超分子ポリマーの化学および超分子安定性のバランス

Weijie Zhang1, Feihu Wang1, Han Wang1

  • 1Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

Journal of the American Chemical Society
|May 16, 2025
PubMed
まとめ

カンプトテシン (CPT) のオリゴエチレングリコール (OEG) 改変により,自己組み立て可能な超分子ポリマー (SP) が作られ,抗がん効果が強化された. 特定のリンカーを持つSPからCPTがより早く放出されることで,結腸がんのモデルにおける腫瘍抑制と生存率が改善された.

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