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Updated: May 23, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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ソマティック・エピミュテーションによるクローン・トレーシングは,血液の老化の動態を明らかにする

Michael Scherer1,2, Indranil Singh3,4, Martina Maria Braun1,5

  • 1Computational Biology and Health Genomics, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.

Nature
|May 21, 2025
PubMed
まとめ

研究者は,DNAメチル化を使用して幹細胞の分化とアイデンティティを追跡するためのトランスゲンフリー方法であるEPI-Cloneを開発しました. このアプローチにより,マウスとヒトの両方の血液形成性幹細胞の 精密な系統追跡が可能です.

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