関連する実験動画

Updated: Sep 20, 2025

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
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Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

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CTC1-STN1-TEN1は,DNA末端切除ブロックによるDNA断裂修復経路の選択を制御する

Cody M Rogers1, Hardeep Kaur1, Michelle L Swift2

  • 1Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Science (New York, N.Y.)
|May 22, 2025
PubMed
まとめ

CTC1-STN1-TEN1 (CST) 複合体は,DNA末端切除を抑制することによってDNA修復経路の選択を制御する. CSTの機能不全は,がん治療に対する耐性を引き起こし,DNAの二重鎖破裂 (DSB) 修復に影響を与えます.

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