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Updated: Jun 12, 2025

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
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核酸における陽子結合型変異の運動解剖は,pH依存型NMRと化学的変異を統合することによって行われる

Yeongjoon Lee1, Rohit Roy2, Stephanie Gu3

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States.

Journal of the American Chemical Society
|May 27, 2025
PubMed
まとめ

核酸のプロトンの移転は,拡散制限の速いステップです. この研究は,DNAとRNAのプロトネーション率とpH応答に影響を与える,形状選択と誘導的適合を含む多様な運動メカニズムを明らかにしています.

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