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Updated: Sep 19, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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イリジウム触媒ナイトレン媒介のエナチオセレクティブ1,2-ヒドリドシフト,キラル δ-ラクトーム合成のためのアトラクティブ・ノンコヴァラント相互作用によって可能

Qian-Kun Fan1, Zi-Qian Bai1, Gang He1,2

  • 1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Journal of the American Chemical Society
|June 3, 2025
PubMed
まとめ

触媒エナチオセレクティブの1,2水素シフトは,ニトロネ媒介戦略を用いて達成された. この方法は,カルボケーションを生成し,非共性相互作用を通じてステレオ化学を制御し,貴重なラクトーム製品を生成します.

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