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Updated: Sep 19, 2025

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
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Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET

Published on: August 17, 2022

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単分子テトラ受容体アゴニストの分子設計

Tristan C Dinsmore1, Jacob E Cortigiano1, Siyuan Xiang1

  • 1Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States.

Journal of the American Chemical Society
|June 3, 2025
PubMed
まとめ

GLP-1R,GIPR,GcgR,Y2Rを含む4つの代謝受容体を標的とした新しいテトラアゴニストを開発した. この突破は,受容体クラスの違いを克服することによって,代謝障害に対する単剤治療を可能にします.

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