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Updated: Sep 19, 2025

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
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CREMは,NK細胞におけるCARとIL-15のシグナリングの規制チェックポイントです

Hind Rafei1,2, Rafet Basar1,2, Sunil Acharya1,2

  • 1Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature
|June 4, 2025
PubMed
まとめ

サイクルAMP応答要素調節器 (CREM) は,キメリック抗原受容体 (CAR) 自然キラー (NK) 細胞機能を調節する. CREMをターゲットにすると,腫瘍に対するCAR-NK細胞の有効性が向上します.

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