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Updated: Sep 19, 2025

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
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アリルハリドをCu (II) カタリストによって効率的にアミナ化する

Christina N Pierson1, Teresa Horak1, Willi M Amberg1

  • 1Department of Chemistry, University of California, Berkeley, California 94720, United States.

Journal of the American Chemical Society
|June 9, 2025
PubMed
まとめ

アリルハリドと窒素核愛素を用いた銅触媒化アミネーション反応が調査された. アニリン形成の安定性と効率性を向上させる新しいCu (II) 触媒サイクルが特定されました.

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Preparation of 1° Amines: Azide Synthesis

Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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