関連する実験動画
Updated: Jun 12, 2025
08:14
Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
9.3K
神経内分泌細胞は 砂漠のヘッジホッグの信号で 再生を指揮する
William Kong1, Wan-Jin Lu1, Megha Dubey2
1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cell
|June 10, 2025
まとめ
砂漠のヘッジホッグ (Dhh) は,メゼンキマ細胞を刺激することで,組織修復をオーケストラします. この上皮-メセンキムフィードバック (EMF) 経路は,呼吸道と臓の小島を損傷から保護し,再生と病気の潜在的な治療戦略を提供します.
科学分野:
- 細胞生物学
- 再生医療
- 発達生物学
背景:
- 哺乳類の再生メカニズムは まだ十分に理解されていません
- 神経内分泌細胞は 組織修復に重要な役割を果たします
- 生理学的反応の鍵となるのは,上皮細胞とメゼンキマの相互作用です.
研究 の 目的:
- 哺乳類の再生における砂漠ヘッジホッグ (Dhh) の役割を明らかにする.
- エピテリア・メゼンキマフィードバック (EMF) 信号伝達経路を調査する.
- EMFの治療の可能性を探る
主な方法:
- 神経内分泌細胞からの DHHの分泌を研究した.
- DHに対するメゼンキマ細胞の反応を調査した.
- 損傷後の組織保護と再生を評価した (SO2,インフルエンザ,SARS-CoV-2,STZ).
- 小分子ヘッジホッグ経路アゴニストを使用した.
主要な成果:
- DHはメゼンキマ細胞からの再生反応を誘発し,最初の信号を放大します.
- EMFシグナリングはSO2とウイルス感染から哺乳類の呼吸道を保護します.
- Dhh媒介のEMFシグナリングは,マウスの臓小島をストレプトゾトシン誘発の損傷から保護する.
- ヘッジホッグ経路阻害剤の使用は糖尿病の発生率と相関しており,ヒトの小島におけるEMFの役割を示唆しています.
結論:
- Dhh媒介のEMFシグナリングは哺乳類の組織再生と保護のための重要なメカニズムです.
- EMFシグナリングのターゲティングは,呼吸道および臓疾患の治療の可能性を提供します.
- 小分子アゴニストは,化学的および感染症の傷害から保護し,糖尿病の治療に希望を示しています.
関連する概念動画
02:33Hedgehog Signaling Pathway
7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
01:15Neurogenesis and Regeneration of Nervous Tissue
739
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
739
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
01:33Whole Body Regeneration
3.3K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.3K
01:19Overview of Regeneration and Repair
4.0K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
4.0K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K