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Updated: Jun 13, 2025

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
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Published on: February 5, 2020

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制御された順次トランペプチデーション反応のためのエンジニアリングされた基板特異性を持つアスパラギニルリガゼ

Yan Zhou1, Simon J de Veer1, Tristan J Tyler1

  • 1Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia.

Journal of the American Chemical Society
|June 11, 2025
PubMed
まとめ

設計されたアスパラギニルリガゼは 新しいタンパク質の設計の可能性を提供します OaAEP1の単一の変異 (Y188A) は,直交基板特異性を生み出し,連続反応と新しいペプチド合成を可能にします.

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