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サイトラビン誘発性神経毒性のメカニズム

Jia-Cheng Liu1, Dongpeng Wang1,2, Elsa Callen1

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Nature
|June 25, 2025
PubMed
まとめ

サイタビンなどのサイチジン類は,DNAの脱メチル化と修復に干渉することで,神経細胞のDNA損傷を引き起こします. これは特定のがん薬の神経毒性を説明します

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