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Updated: Sep 18, 2025

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
16:16

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

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放射性標識付き光スイッチ可能なGタンパク質結合受容体アンタゴニストは,光スイッチングに関連したリガンド結合運動を明らかにする

Lars C P Binkhorst1, Ivana Josimovic1, Bas De Boer1

  • 1Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Journal of the American Chemical Society
|June 26, 2025
PubMed
まとめ

研究者は,光に依存した結合運動を研究するために,最初の放射性標識付きの光交互性リガンド [3H]VUF26063を開発した. このツールは,ヒスタミンH3受容体 (H3R) の活性をリアルタイムで制御し,光薬学を前進させます.

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