関連する実験動画

Updated: Sep 17, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

12.4K

偽ウリジンRNAは,エンドリソームの処理とTLRの関与を損なうことで免疫検出を回避する

Marleen Bérouti1, Mirko Wagner2, Wilhelm Greulich1

  • 1Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany.

Cell
|June 28, 2025
PubMed
まとめ

トール型受容体 (TLR) は外来RNAを感知する. mRNA技術の重要な特徴であるTLRの活性化を防止するが,そのメカニズムは不明であった. この研究は,偽ウリジンRNAがTLRの認識を回避する方法を示しています.

キーワード:
N1-メチルプセウドウリジンPLD3 についてPLD4 についてRNase T2 についてTLR7 についてTLR8 についてトール型受容体エンドリソソームヌクレアゼ免疫刺激プセウドウリジン

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Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection06:44

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Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution10:53

Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution

Published on: January 16, 2017

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