関連する実験動画

Updated: Sep 17, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

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LAG-3とT細胞受容体の近接は,T細胞活性化と自己免疫を抑制する

Jasper Du1, Hui Chen2, Jia You1

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.

Cell
|July 1, 2025
PubMed
まとめ

LAG-3受容体をT細胞に標的にすることは,自己免疫疾患の治療の鍵です. 新しい双特定抗体はLAG-3の機能を強化し,T細胞受容体と結合し,病原性T細胞を効果的に抑制する.

キーワード:
CD3εLAG-3 についてLck についてMHCクラスIITCR について自己免疫性バイスペシフィックT細胞サイレンサーcis近さ凝縮する免疫療法

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