関連する実験動画

Updated: Sep 17, 2025

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
10:28

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors

Published on: August 17, 2019

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臨床的に有効な非筋肉ミオシンII小分子阻害剤の開発

Laszlo Radnai1, Erica J Young2, Carlos Kikuti3

  • 1Department of Molecular Medicine, The Scripps Research Institute and The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA; Department of Neuroscience, The Scripps Research Institute and The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.

Cell
|July 2, 2025
PubMed
まとめ

MT-228とMT-110という新しい非筋肉ミオシンII阻害剤は,高い選択性と脳への浸透性を示しています. メタフェタミン使用障害 (MUD) の治療戦略は有望で,安全性が向上しています.

キーワード:
ブレビスタチン癌について心筋ミオシンII高解像度タンパク質阻害剤構造薬用化学メタンフェタミン分子モーター非筋肉のミオシンII薬物使用障害治療的な

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