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関連する概念動画

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

23.5K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
23.5K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.0K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.0K
What is Gene Expression?01:42

What is Gene Expression?

170.8K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
170.8K
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

137
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
137
Structure of a Gene01:30

Structure of a Gene

13.4K
A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
13.4K
Epigenetic Regulation01:46

Epigenetic Regulation

31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K

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Updated: Sep 17, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.6K

遺伝子発現の強化

Filip Nemčko1, Alexander Stark1,2

  • 1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.

Science (New York, N.Y.)
|July 3, 2025
PubMed
まとめ
この要約は機械生成です。

新しく発見されたコファクターは 転写因子の結合を全ゲノムで安定させます この発見により 遺伝子調節に関する理解が深まり 治療の新たな標的となるのです

さらに関連する動画

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.6K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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関連する実験動画

Last Updated: Sep 17, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.6K
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.6K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.6K

科学分野:

  • 分子生物学
  • 遺伝学
  • 生物化学

背景:

  • 転写因子は特定のDNA配列に結合することで遺伝子発現を制御する.
  • 転写因子結合の安定性は精密な遺伝子調節に不可欠である.
  • ゲノム全体の転写因子結合の安定性を支配するメカニズムは完全に理解されていません.

研究 の 目的:

  • 転写因子結合の安定性に影響を与える新しい因子を特定する.
  • ゲノム全体にわたる転写因子の関連性における以前に未知のコファクターの機能を明らかにする.

主な方法:

  • ゲノム全体のクロマチンの免疫降水とシーケンシング (ChIP-seq) を採用した.
  • コファクター相互作用を特徴付けるために生化学的測定を行った.
  • CRISPRベースのスクリーニングで新しいコファクターが特定されました.

主要な成果:

  • 転写因子の結合を有意に安定させる,以前未知のコファクターが特定されました.
  • このコファクターの機能は多数のゲノム部位で観察されました
  • コファクター機能の喪失は,転写因子の安定性を低下させ,遺伝子発現パターンを変化させた.

結論:

  • 新しいコファクターは,全ゲノムにわたる転写因子結合の安定化に重要な役割を果たします.
  • この発見は 遺伝子調節の基本的メカニズムに光を当てました
  • 特定されたコファクターは,遺伝子不調を含む疾患の潜在的な治療標的を表しています.