関連する実験動画

Updated: May 4, 2026

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
10:05

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

Published on: November 13, 2015

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PHF7による細胞再プログラムにより,心筋梗塞後の心臓機能が改善される

Glynnis Garry Bann1,2, Matthieu Dos Santos1, Kenian Chen3

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.).

Circulation
|July 9, 2025
PubMed
まとめ

単一の表遺伝因子であるPHF7は 心臓損傷のあるマウスの 線維細胞を心臓細胞に効果的に再プログラムします この発見は 心臓の機能と再生を向上させることで 心臓不全の治療に 新しい戦略を提示しています

キーワード:
細胞を再プログラムする直接的なセル再プログラム技術エピゲノミクス心不全心筋梗塞

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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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Cardiomyopathy IV: Restrictive Cardiomyopathy

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Cardiomyopathy VI: Nursing Management01:29

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Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
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Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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