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Updated: Sep 16, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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レザーピン生物合成におけるステレオ化学的制御の酵素的基礎

Jiaqing Cao1, Jingxiao Zhong1,2,3, Feng Li1,4

  • 1State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Journal of the American Chemical Society
|July 9, 2025
PubMed
まとめ

研究 者 たち は,植物 が 複合 的 な 薬剤 で ある リザーピン を 作り出す 方法 を 発見 し まし た. 彼らは2段階の酵素プロセスが 独特の構造を生み出し 自然製品を合成する新しい方法を提供することを発見しました

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SN1 Reaction: Stereochemistry

This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
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If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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