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Updated: Sep 16, 2025

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ヒトのテロメラーゼ二分子の冷凍-EM構造は,H/ACA RNP媒介の二分化を示している

Sebastian Balch1, Zala Sekne1, Elsa Franco-Echevarría1

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Science (New York, N.Y.)
|July 10, 2025
PubMed
まとめ

この研究は,ヒトのテロメラーゼ二重体,26個のサブユニット複合体の 凍結EM構造を明らかにした. このダイマー形成は,ヒンジとACAボックス (H/ACA) RNPによって媒介され,テロメラーゼの組立と機能に不可欠である.

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