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Updated: Sep 15, 2025

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
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プロファージ は 細胞 表面 の 受容 器 を 遮断 し,その ウイルスの 子孫 を 保存 する

Véronique L Taylor1, Pramalkumar H Patel1, Megha Shah1

  • 1Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Nature
|July 16, 2025
PubMed
まとめ

バクテリオファージはZipと呼ばれるタンパク質を使って 他のウイルスが同じ細胞に感染するのを防ぎます このメカニズムである 抗クロノス効果は 病原菌の子孫を保護し 微生物のコミュニティにおける ウイルスの拡散を促進します

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Viral Replication: Lysogenic Cycle

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In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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