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Updated: Sep 15, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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RiPPにおけるα-ケトグルタレート依存型ダイオキシゲネーゼ誘導マクロサイクリング

Yinzheng Xia1, Ying Shi1, Zhixi Xiao1

  • 1State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center of Nanjing University, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society
|July 16, 2025
PubMed
まとめ

この研究では,α-ケトグルタレート依存型ダイオキシゲナーゼ (αKGDs) が,リボソーム合成および翻訳後に改変されたペプチド (RiPPs) でマクロサイクリングを触媒化する事が明らかになった. 2つのコンポーネントのJMJDシステムは,ランチペプチドコルシンにユニークなCys-Tyrクロスリンクを形成します.

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