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Updated: Sep 15, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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メカノステリクスに関するスポットライト:大容量のマクロサイクルがロタキサンにおける機能群反応を促進する [2]

Thomas Pickl1, Claire Stark1, Diego Briganti1,2

  • 1Catalysis Research Center (CRC) & TUM School of Natural Sciences, Department of Chemistry, Technical University of Munich, Ernst-Otto-Fischer Str. 1, 85747 Garching, Germany.

Journal of the American Chemical Society
|July 17, 2025
PubMed
まとめ

機械的に結合した分子では,大型のマクロサイクルは通常反応性を減少させます. しかし,この研究は,マクロサイクルがFmocの脱保護を36倍加速する [2]ロタキサンを明らかにし,絡み合いが化学反応性を高めることを示しています.

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