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Updated: Sep 14, 2025

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
11:36

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing

Published on: July 3, 2016

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単一変異による構成変化によるニューデリーメタロβ-ラクタマースの阻害剤依存性耐性

Liwen Huang1,2,3,4, Tsz-Fung Wong1,2, Qipeng Cheng2,5

  • 1Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong SAR, China.

Journal of the American Chemical Society
|July 21, 2025
PubMed
まとめ

ニューデリーメタロβ-ラクタマース (NDM) 変異は,形状の変化によって進化し,M154L変異はタンパク質の動態を調節することによって抵抗性を高めます. これはNDM阻害剤の設計のための新しい戦略を明らかにします.

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