まとめ
がんに関連したメト・オンコゲンは,成長因子受容体に関連する新型チロシンキナーゼです. その遺伝子は,システィック線維症の近く,染色体7に位置しています.
科学分野:
- 分子生物学は分子生物学である.
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
背景:
- メット腫瘍遺伝子は,ヒト細胞系 (MNNG-HOS) から分離されました.
- 2つのトランスクリプトクラスは,メットプロトオンコゲンロカスから発生し,オンコゲンは異常なRNAを発現します.
- 以前の研究では,異なった腫瘍遺伝子の異常なRNAが,既知の2つのトランスクリプトと配列を共有していることが示された.
研究 の 目的:
- ヒトのメト・オンコゲネの部分ヌクレオチド配列を解析を行う.
- 発見された腫瘍遺伝子が,既知の腫瘍遺伝子および成長因子受容体との関係を決定する.
- メット遺伝子の染色体位置をマップする.
主な方法:
- ヒトメト腫瘍遺伝子の部分的な核酸配列解析.
- シーケンスホモロジー分析は,既知のキナーゼファミリーと特定の遺伝子 (インスリン受容体,ウイルス性ABL) と比較します.
- In situ 染色体ハイブリッド化により,メット遺伝子の位置をマッピングする.
主要な成果:
- メット・オンコゲンは,タンパク質キナーゼ・オンコゲンと成長因子受容体に関連している.
- Metはセリン/スレオニンキナーゼよりもチロシンキナーゼに近いホモロジーを示しており,特にヒトインスリン受容体とウイルスのABL遺伝子に近い.
- ヒト染色体7帯7q21-q31にマッピングされたインシットウ・ハイブリダイゼーションは,他のキナーゼと,急性非リンパ球性白血病の欠損に関連した領域と区別されています.
結論:
- メト・オンコゲンは,成長因子受容体と構造的に類似した新しいチロシンキナーゼを表しています.
- メト (7q21-q31) の染色体位置は,他のキナーゼと区別され,特定の白血病と関連しており,有意である.
- メトゲンロクスはまた,システィック線維症と関連しており,潜在的なプレオトロプ的役割や複雑な遺伝子相互作用を示唆しています.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
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