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Updated: Sep 14, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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PI3KαへのRAS結合を促進する分子接着剤は,インスリンなしでグルコースの吸収を促進する

Koji Terayama1, Shinji Furuzono1, Nicole Fer2

  • 1Cardiovascular Metabolic Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

Science (New York, N.Y.)
|July 24, 2025
PubMed
まとめ

新しい分子接着剤であるD223とD927は,RASタンパク質に対するフォスホイノシチド3キナーゼα (PI3Kα) の結合親和性を高め,グルコースの吸収を強化する. これらの化合物はインスリンなしで 血糖を効果的に低下させ 糖尿病モデルを改善します

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