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Updated: Sep 14, 2025

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
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新たに設計されたpMHC結合剤は,T細胞媒介によるがん細胞に対する細胞毒性を促進する

Kristoffer Haurum Johansen1, Darian Stephan Wolff2, Beatrice Scapolo1,2

  • 1Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Science (New York, N.Y.)
|July 24, 2025
PubMed
まとめ

研究者は,がん特有のT細胞受容体 (TCR) を標的とするミニバインダーを設計するために,ジェネラティブモデルを使用して新しいプラットフォームを開発しました. このアプローチにより,高親密性の結合剤が開発され,メラノーマ細胞を殺害し,精密免疫療法に希望を示しました.

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