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Updated: Sep 14, 2025

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
06:44

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Published on: April 6, 2017

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構造的に特徴づけられたNi (III) -Hydroxo複合体による基礎度制御C-H結合活性化

Hung-Ruei Pan1, John Wu1, Chun-Ming Tsai1

  • 1Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.

Journal of the American Chemical Society
|July 25, 2025
PubMed
まとめ

研究者らは,強いC−H結合を活性化する安定したニッケル−ヒドロキソ複合体を開発した. この発見は,選択的酸化と水素原子移転反応のメカニズムに関する新しい洞察を提供します.

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Cyanohydrins are formed when cyanide nucleophiles and carbonyl compounds like aldehydes and ketones react. A strong base, the cyanide ion, catalyzes cyanohydrin formation. The ions are generated from HCN under aqueous conditions. Once the cyanide ions are generated, the first step involves the nucleophilic attack of the cyanide ions on the electrophilic carbonyl carbon. This attack shifts the π electrons from the C=O to the oxygen atom forming the alkoxide ion intermediate. The alkoxide anion...
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