双極性障害

Balwinder Singh¹, Holly A Swartz², Alfredo B Cuellar-Barboza³

¹Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Lancet (London, England)

|July 25, 2025

まとめ

双極性障害は世界中で4千万人に影響を与え診断の難しさと重大な負担を伴いますケタミンのような新しい治療法を探求し患者のケアを改善しています

科学分野:

精神医学と神経科学
メンタルヘルスの研究

背景:

双極性障害はマニア/ヒポマニアとうつ病によって特徴付けられ,世界中で4千万人に影響を与えます.
心理的・社会的・医療的・経済的負担があり死亡リスクも高まります
症状が他の精神疾患と重なり合っているため,診断の遅延は一般的です.

研究の目的:

双極性障害の病理生理学と危険因子の現在の理解をレビューする.
現在の治療戦略と新たな治療戦略を概説する.
双極性障害の研究と治療の将来の方向性を特定する

主な方法:

双極性障害の研究における最近の進歩の文献レビュー.
遺伝的,感染症的,ミトコンドリア的原因に関する情報の合成
薬剤療法,心理療法,ライフスタイルの改変のアプローチの概要
新しい介入と将来の研究方法の探求

主要な成果:

多遺伝子リスク,感染症,ミトコンドリア要因は双極性障害に関わっている.
患者中心の薬物療法,心理療法,ライフスタイルの変化は治療の重要な要素です.
ケタミン,エスケタミン,神経調節などの新しい治療法は有望です.

結論:

標的治療の開発には病理生理学の研究が不可欠です
心理社会的な介入へのアクセスを拡大し,治療抵抗性に対処することが優先事項です.
将来のケアでは,新しい薬理学と神経調節技術が統合され,総合的な治療が可能になります.

さらに関連する動画

05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.5K

08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.9K

関連する概念動画

01:30

Bipolar Disorder

144

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

144

01:25

Borderline Personality Disorder

142

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...

142

01:24

Mania and Antimanic Drugs: Overview

321

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...

321

01:20

Personality Disorders: Schizotypal and Histrionic

165

Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...

165

01:18

Depression: Overview

343

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

343

01:27

Panic Disorder

176

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...

176

関連する実験動画