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Updated: Sep 13, 2025

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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人間のIAPP繊維の構造は膜とpH条件を反映する

Venus Singh Mithu1, Karin Giller1, Evgeny Nimerovsky1

  • 1Department of NMR-based Structural Biology, Max Planck Institute of Multidisciplinary Sciences, Göttingen 37077, Germany.

Journal of the American Chemical Society
|August 1, 2025
PubMed
まとめ

生理学的に重要なモデルは,2型糖尿病におけるヒトアミロイドポリペプチド (hIAPP) 線維の構造を明らかにする. 膜相互作用と細胞外pHは,hIAPPの集積とβ細胞機能不全を理解するために重要である.

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