関連する実験動画

Updated: Sep 13, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

435

溶解性Notchアゴニストの設計は,T細胞の発達を促し,免疫を高める

Rubul Mout1, Ran Jing1, Mayuri Tanaka-Yano2

  • 1Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Cell
|August 2, 2025
PubMed
まとめ

研究者は細胞運命を制御する重要なノッチ受容体を活性化する 新種の溶解性タンパク質複合体を開発しました これらのエンジニアリングされたアゴニストは,T細胞の差別化を効果的に促進し,免疫反応を強化し,免疫療法と治療開発のための新しい道を開きます.

キーワード:
ノッチ・シグナルT細胞の発達T細胞免疫計算式タンパク質設計iPSC由来T細胞免疫療法タンパク質アゴニスト溶性 ノッチ アクティベーションワクチン

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