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Updated: Sep 12, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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本質的に乱れたタンパク質ミミックの繰り返し合成

Jian Wan1, Zhenhai Tang1, Qinmeng Zhong2

  • 1College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.

Journal of the American Chemical Society
|August 5, 2025
PubMed
まとめ

化学者は反復指数関数的な成長を用いて,人工的に内在的に乱れたタンパク質 (IDP) とその周期的模倣を合成した. この方法は分子量と立体化学を正確に制御し,相変化の行動に影響を与えます

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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