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Updated: Sep 12, 2025

Ubiquitin Chain Analysis by Parallel Reaction Monitoring
08:33

Ubiquitin Chain Analysis by Parallel Reaction Monitoring

Published on: June 17, 2020

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マルチステート構造決定とダイナミクス分析は,ユビキチンC末端ヒドロラーゼにおけるユニークなユビキチン認識メカニズムを明らかにする

Mayu Okada1, Yutaka Tateishi1, Eri Nojiri2

  • 1Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan.

Journal of the American Chemical Society
|August 6, 2025
PubMed
まとめ

この研究では,タンパク質のダイナミクスを視覚化し,一時的な形状を機能に結びつける新しいNMR法が導入されています. この方法は酵母ウビキチンヒドロラーゼ1の大きな動きを明らかにし,酵素活性には極めて重要です.

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