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Updated: Sep 12, 2025

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

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α-シヌクレインは,SNAREに依存した管状の膀の改造を促す

Qun Li1,2,3, Tao Hu1, Fan Li1

  • 1Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.

Journal of the American Chemical Society
|August 6, 2025
PubMed
まとめ

アルファシヌクレイン (α-syn) は,シナプス胞に素早く管状の突起を形成し,SNAREタンパク質を必要とします. この新しいメカニズムは,パーキンソン病 (PD) のシナプス機能障害に寄与する.

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SNAREs and Membrane Fusion

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In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
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Export of Misfolded Proteins out of the ER

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